Case Study / RCSB PDB

Making science's
most-used database
actually usable

A full UX redesign of the RCSB Protein Data Bank help section โ€” tackling poor information architecture, WCAG accessibility failures, and navigation patterns that sent millions of researchers straight to Google instead.

Timeline Sep 2024 โ€“ May 2025
Role UX Designer
Team 4 Designers
Platform rcsb.org ยท Desktop-primary
Context Rutgers UXD Practicum

01 โ€” At-a-Glance

The problem,
the solution

The RCSB Protein Data Bank is the US repository for 3D structural data of biological molecules, visited by millions of researchers and students annually. Its help section โ€” the primary support resource for a highly diverse user base โ€” suffered from poor information architecture, accessibility gaps, and navigation patterns that failed both novice and expert users alike.

Problem

The RCSB PDB Help Page lacked clear organization, intuitive navigation, and accessible content, making it difficult for users โ€” especially students and new researchers โ€” to efficiently find the support they need. Many users bypassed the help section entirely, turning to Google instead.

Solution

A restructured information architecture with 8 logical categories, a search-first approach, hybrid progressive disclosure, and full WCAG 2.1 AA compliance โ€” balancing the needs of expert researchers and first-time student users within a single system.

20+
Survey responses across 2 research phases
10+
User interviews with active PDB researchers
95%
Task success rate โ€” up from 70%
โ€“30%
Reduction in user error rate

02 โ€” My Role

Research, IA, Wireframing,
Prototyping & Testing

As one of four designers on the Rutgers UXD Practicum team, I contributed across the full design process โ€” from shaping the research plan to validating the final prototype. This was the most research-intensive project in my portfolio: 16 weeks of structured UX process with real stakeholders and real constraints.

๐Ÿ”ฌ
Mixed-Methods Research
Designed and distributed Typeform/Google Forms surveys, conducted stakeholder interviews, and ran unmoderated first-click tests via Optimal Workshop.
๐Ÿ—‚๏ธ
Information Architecture
Led restructuring of the flat 40+ link sidebar into 8 logical, labeled categories. Ran card sorting and tree testing to validate groupings with real users.
๐Ÿ–ฅ๏ธ
Prototyping & A/B Testing
Built two distinct help page layouts in Figma and ran A/B testing with 5 moderated participants to determine which navigation model best served both user types.
โ™ฟ
Accessibility Audit
Conducted a systematic visual design audit documenting WCAG 2.1 AA violations โ€” contrast failures, missing ARIA labels, small tap targets, and keyboard navigation gaps.
๐Ÿ“Š
Usability Testing
Facilitated moderated and unmoderated testing sessions (5 + 15 participants) to validate the redesign against baseline metrics before and after iterating.
๐ŸŽจ
Visual Design
Redesigned typography hierarchy, spacing, color contrast, and interactive component states to meet accessibility standards while improving visual clarity.

03 โ€” Research

Two phases,
six methods

We used a mixed-methods approach across two phases โ€” discovery and validation โ€” spanning roughly 16 weeks. The goal was to understand not just what users said they wanted, but what their actual behavior revealed about the help page's failure modes.

Method What we studied Sample Phase
Typeform Survey Help page usage, search behavior, content preferences 20+ respondents Discovery
Google Forms Survey Quantitative usability + satisfaction ratings 15 respondents Discovery
Stakeholder Interviews Moderated sessions with active PDB users 5 participants Discovery
Unmoderated Testing First-click tests via Optimal Workshop 15 participants Validation
Competitive Analysis UniProt, PDBe, Ensembl, NCBI help sections 4 competitors Discovery
A/B Prototype Testing Two help page layouts compared in Figma 3 moderated sessions Validation

How Might We

"How might we redesign the RCSB PDB help page so that both novice students and expert researchers can efficiently find the support they need โ€” without compromising on depth or accessibility?"

04 โ€” Key Findings

What the data
told us

57%
of users had never used the Help page before their visit
43%
turned to Google first instead of the Help section
71%
rated help page usability as 'neutral' or worse
60%
struggled with long, text-heavy content with no visual hierarchy

Usability Issues Identified

Information hierarchy: Critical content was buried in long text blocks. Users relied on Ctrl+F to find anything, bypassing navigation entirely.
Sidebar navigation: Labels were unclear โ€” 'Explore Structures' and '3D Structures' created confusion about where specific topics lived.
Search failures: The help page search returned inconsistent results. A chemistry professor described it as "50/50 โ€” I either find what I need or end up reading about something completely unrelated."
Accessibility gaps: Visual contrast failures, missing screen-reader labels, no keyboard navigation support, and unlabeled interactive elements throughout.
Expert vs. novice divide: A single flat information architecture served neither group well โ€” experts needed deep reference, beginners needed guided onboarding.

Voices from Users

"Even though it's very robust, it's very clunky. Once I find something I write it down and have my students repeat it."

โ€” Chemistry Professor, Wayne State University ยท Usability testing participant

"The current help page is overwhelming. I'd rather just Google it."

โ€” RIT Student, Victoria Greever ยท Usability testing participant

05 โ€” Design Process

Two personas,
one system

Research revealed two distinct user groups with fundamentally opposing needs. Designing a single help system that served both without condescending to one or overwhelming the other was the core design challenge.

๐Ÿ”ฌ
The Researcher
Persona 01

Profile

  • PhD or faculty level, uses PDB multiple times weekly
  • Needs deep reference material, API docs, advanced search guidance
  • Frustrated by poor searchability and inconsistent results

Goals

  • Find specific technical documentation fast
  • Access API reference without wading through beginner content
  • Reproduce search queries reliably
๐ŸŽ“
The Student
Persona 02

Profile

  • Undergrad or early grad student, infrequent PDB user
  • Needs step-by-step guidance, visual cues, and FAQs
  • Overwhelmed by information density and jargon

Goals

  • Understand what the help page offers before diving in
  • Find a specific answer without reading dense documentation
  • Complete a class assignment without calling their TA

IA Overhaul

From 40+ unlabeled links
to 8 logical categories

The original flat sidebar had 40+ unlabeled links with no clear grouping. We restructured the help section based on user mental models surfaced through card sorting and tree testing.

01
Explore Structures
search, browse, sequence/structure/chemical similarity
02
View & Analyze
summary pages, Mol* viewer, sequence viewers
03
Tools & Downloads
alignment tools, APIs, batch downloads
04
Structure Quality
quality assessment, ligand quality, computed models
05
Deposition
guidance for depositing new structures
06
Learning & Support
getting started, FAQs, glossary
07
External Resources
external databases and knowledgebases
08
Discipline-Specific
crystallography, EM, NMR, structure prediction

Wireframing & A/B Testing

The split result that led to a
hybrid design

We prototyped two distinct help page layouts in Figma and tested them with 5 moderated participants. Help Page 1 used progressive disclosure (hover-to-expand), while Help Page 2 showed all links inline. Testing revealed a split preference โ€” expert users preferred the density of Page 2, while novice users found Page 1 less overwhelming. The final design incorporated a hybrid approach: visible top-level categories with expandable sub-sections.

Key insight from A/B testing: No single layout worked for all users. The hybrid approach โ€” top-level categories visible, sub-items expandable โ€” balanced expert efficiency with novice approachability. This became the core structural decision that unified both personas.

Accessibility Interventions

Accessibility as a design
constraint, not a checklist

Contrast: Fixed all text/background combinations failing the 4.5:1 WCAG AA ratio โ€” including the sidebar, search bar, and card components.
Screen reader support: Added ARIA labels to all interactive elements, icon buttons, and tooltip triggers that previously had no accessible names.
Tooltips: Added descriptive tooltips to jargon-heavy terms (e.g., 'Mol* Viewer', 'Ligand Quality') to support novice users without cluttering the interface.
Keyboard navigation: Ensured all interactive elements were reachable via Tab key and had visible focus indicators.
Breadcrumbs: Added clear breadcrumb navigation (Home โ†’ Help โ†’ Category โ†’ Article) to address the disorientation users reported when navigating deep into the help tree.

06 โ€” Visual Design Audit

Every issue documented
before a single pixel moved

As part of the research phase, the team conducted a systematic visual design audit of the existing RCSB PDB Help section. Every issue documented below was identified before any redesign work began, and each directly informed a design decision in the final prototype.

Starting point โ€” the live help page before any intervention

Original RCSB PDB Help page โ€” information-dense, flat hierarchy, no visual grouping
Original RCSB PDB Help page โ€” information-dense, flat hierarchy, no visual grouping

Issue 01

Cognitive Overload โ€” Gestalt & Whitespace

The grid layout organized information into blocks, but right-side sections (Deposition Resources, Learning Resources, Video Tutorials) lacked clear separation โ€” causing cognitive overload. The left-side sidebar clustered related links but insufficient contrast and spacing between subsections created a visually cluttered appearance.

Fix applied: Consistent negative space around sections, increased paragraph spacing, clear section dividers, and progressive disclosure (collapsible sections) to reduce immediate cognitive load.
Crowded grid layout showing cognitive overload issues

Issue 02

WCAG 2.1 AA Contrast Violations

The excessive use of blue across the page lacked sufficient contrast. Lighter shades of blue used in the sidebar navigation failed to meet the WCAG 2.1 AA minimum contrast ratio of 4.5:1 for normal text. 27 elements failed contrast checks across the page.

Fix applied: Secondary color introduced to visually separate sections. All text/background combinations verified against WCAG 2.1 AA contrast ratios (4.5:1 normal text, 3:1 large text). Color coding used to distinguish navigation, content areas, and links.
WCAG 2.1 AA contrast violations audit โ€” 27 failing elements identified

Issue 03

Typography โ€” Readability & Hierarchy

Body text size was notably small across content-rich sections. Headings and subheadings provided some structure, but description text and subcategories lacked distinct differentiation. Bullet points under dense content had insufficient visual contrast โ€” difficult to scan and distinguish from body copy.

Fix applied: Body text size increased. Line spacing set to minimum 1.5x. Bolder subheadings, increased font weight for critical links, improved bullet indentation for clearer content hierarchy.
Navigation layout showing small tap targets and typography issues

Issue 04

Navigation Hierarchy โ€” Proximity & Alignment

Navigation elements on the right side lacked visual weight โ€” easy to miss entirely. Left sidebar menu items were cramped together, hindering quick readability and making it difficult for users to parse the information hierarchy at a glance. 43% of users reported bypassing the sidebar navigation entirely.

Fix applied: Distinct section dividers added. Increased line spacing and improved alignment. Clear breadcrumb navigation (Home โ†’ Help โ†’ Category) introduced to support user orientation. Navigation restructured into 8 logical categories with descriptive labels.
Navigation hierarchy issues โ€” insufficient visual separation and low contrast sidebar

07 โ€” Outcomes & Impact

Measured across
20 test sessions

After iterative testing with 5 moderated and 15 unmoderated participants, the redesigned prototype showed significant improvements across all key metrics compared to the original help section.

Metric Before After Change
Task success rate 70% 95% +25pp
Average task completion time Baseline โ€“20% faster Faster
User error rate Baseline โ€“30% errors Fewer errors
Help page discoverability 43% bypassed Improved findability IA restructure
Accessibility compliance Multiple AA failures WCAG 2.1 AA Compliant

Key Design Decisions

Hybrid progressive disclosure: A/B testing showed no single layout worked for all users. The hybrid approach โ€” top-level categories visible, sub-items expandable โ€” balanced expert efficiency with novice approachability.
Search-first IA: 57% of users had never used the help page because they couldn't find it or find anything in it. Making the search bar prominent, with predictive suggestions and accurate results, was the single highest-impact change.
Accessibility as a core constraint: Rather than treating WCAG compliance as a checklist at the end, accessibility considerations shaped component choices from wireframe stage โ€” particularly for contrast, labeling, and keyboard interaction patterns.
Breadcrumb navigation: Multiple users reported feeling lost when navigating deep into help topics. Breadcrumbs reduced disorientation and improved users' mental model of the site structure.

08 โ€” Final Screens

The redesigned
help system

The final prototype addressed every identified pain point โ€” a search-first homepage, restructured 8-category navigation, WCAG-compliant components, and breadcrumb wayfinding throughout. Two design variants (Design 1 and Design 2) were tested and merged into a hybrid approach.

Before Original RCSB PDB help page โ€” flat hierarchy, 40+ unlabeled sidebar links, no visual grouping

Original help page โ€” flat IA, no visual hierarchy

After โ€” Design 2 Redesigned RCSB PDB help page โ€” Design 2 with category cards and structured sidebar navigation

Redesigned homepage โ€” search-first, 8 categories, card grid

Design 1 โ€” Article / Inner Page with Breadcrumb Navigation

Redesigned RCSB PDB article page โ€” Design 1 with expanded sidebar, breadcrumb navigation and structured content
Design 1 โ€” Breadcrumb wayfinding, expanded sidebar tree, structured article layout

Explore the interactive prototype

Click through the full interactive redesign โ€” both Design 1 and Design 2 variants โ€” on Figma.

Open in Figma โ†’